First Edition, second issue with the author's name in full and not in initials. Title within double rule border, second title page for "Some Uncommon Observations ...", 4-pages of publisher's advertisements at the end. Short tear at margin of title, wormhole running from the title to H8, expanding through some leaves into a larger worm track with slight loss of letters, some light mainly marginal spotting and staining, a few darker spots. Contemporary mottled calf (spine repaired with old vellum, rubbed and scuffed). Owner’s name in ink to title page. The second part is a treatise on ophthalmology and is based on personal observation, making it one of the first scientific treatises to employ the empirical method. An extremely rare book. We can find no other copies available on-line.